ABSTRACT
The present investigation was designed to formulate a natural tablet for the treatment of vaginal candidiasis in order to eliminate side effects that are caused by existing antifungal drugs. Curcumin has promising antifungal activity in comparison with the existing azole antifungal drugs. Bioadhesive curcumin vaginal tablets were prepared by direct compression with different ratios of biadhesive polymers like xanthan gum, guar gum and HPMC. Curcumin tablets were characterized by studies of friability, hardness, hydration, DSC, mucoadhesion, in vitro release and antifungal activity. DSC and FT-IR data indicate there was no interaction between the drug and the excipients and also polymer concentration has some effects on melting point of curcumin. Formulation F3 showed the best results in terms of swelling and mucoadhesion together with prolonged drug release. The antifungal activity of the Curcumin tablet has demonstrated a significant effect against Candida albicans. Hence, the study indicates the possible and effective use of curcumin bioadhesive monolithic vaginal tablet for vaginal candidiasis as a promising natural antifungal treatment
Subject(s)
Curcumin , In Vitro Techniques , Vaginal Creams, Foams, and JelliesABSTRACT
The objective of the present study is to develop and investigate the swelling behavior of pH-sensitive Superporous Hydrogel [SPH] and SPH composite [SPHC]. A novel superporous hydrogel containing poly [methacrylic acid-co-acrylamide] was synthesized from methacrylic acid and acrylamide through the aqueous solution polymerization, using N,N-methylenebisacrylamide as a crosslinker and ammonium persulfate as an initiator. SPHCs were made in the same way, except for the using of Ac-Di-Sol as a stabilizer. The synthesized SPH and SPHC were characterized by Fourier-transform infrared spectroscopy, swelling kinetics, porosity, mechanical properties and scanning electron microscopy. The swelling of SPH and SPHC was sensitive towards the pH, ionic strength, and temperature stimuli. The study of the surface morphology of SPH using scanning electron microscopy showed a highly porous structure. SPH polymers showed higher swelling ratio but less mechanical stability compared to SPHC polymers, which showed lower swelling ratio but a higher mechanical stability. With a change in pH from acidic to basic, a considerable increase in swelling was observed. Since the prepared SPH and SPHC swell only in the basic pH, it may be concluded that SPH and SPHC can be used as the pH-sensitive drug delivery system
ABSTRACT
The objective of this study was to prepare and evaluate microparticles of Eudragit and Ethyl cellulose binary blend loaded with theophylline for controlled release. Microparticles were prepared by Phase separation method. The method is quite simple, rapid, and economical and does not imply the use of toxic organic solvents. Solid, discrete, reproducible free flowing microparticles were obtained. The yield of the microparticles was up to 92%. More than 85% of the isolated microparticles were of particle size range of 325 to 455 micro m. The obtained angle of repose,% carr's index and tapped density values were well within the limits, indicating that prepared microparticles had smooth surface, free flowing and good packing properties. Scanning Electron Microscopy photographs and calculated sphericity factor confirms that the prepared formulations are spherical in nature. Prepared microparticles were sTab. and compatible, as confirmed by DSC and FT-IR studies. The prepared formulations were quantitatively analyzed for the amount of encapsulated drug. It was observed that there is no significant release of the drug at gastric pH. The drug release was controlled more than 12 h. Intestinal drug release from microparticles was studied and compared with the release behavior of commercially available oral formulation Duralyn CR 400. The release kinetics followed different transport mechanisms
Subject(s)
Acrylic Resins , Cellulose/analogs & derivatives , Pharmacy , Microscopy, Electron , Polymethacrylic AcidsABSTRACT
The objectives of the present study is to prepare waxes/Tat microspheres loaded with Theophylline, [TP] a well known xanthine bronchodilator, was entrapped into gastro-resistant, biodegradable waxes such as beeswax [BW], cetostearyl alcohol [CSA], spermaceti [SC] and fat cetyl alcohol [CA] microspheres using meltable emulsified dispersion cooling induced solidification technique utilizing wetting agents. Solid, discrete, reproducible free flowing microspheres were obtained converting the liquid drug droplets into solid materials. Prepared waxes/fat microspheres are spherical in shape, have smooth surfaces with free flowing and good packing properties, as evidenced by scanning electron microscope [SEM]. The microspheres were characterized for their particle size, micromeritic properties and encapsulation efficiency. Size of the obtained waxes/fat microspheres ranged between 115 to 850 micro m. Molecular level drug distribution and compatibility of the drug after encapsulation in the waxes/fat microspheres was confirmed by differential scanning calorimetry [DSC] and FT1R spectral studies. The prepared microspheres were analyzed quantitatively for the amount of encapsulated drug. Maximum yield was produced by TP loaded in beeswax [AT] and minimum amount of TP was encapsulated into cetyl alcohol [DT] microspheres. The release of drug was controlled for more than 8 hours. Intestinal discharge of TP from waxes/fat microspheres was studied and compared with the oral formulation of TP [Unieontin[R]-n-400]. Among all the systems studied, TP loaded in cetostearyl alcohol [BT] have shown fastest release whereas slowest release by TP loaded in spermaceti [CT]. The release kinetics followed different transport mechanisms. The release performance was greatly affected by the materials used in microspheres preparations, which allows maximum absorption in the intestine